Cancer miRNA Regulatory Network

This page contains all miRNA mediated regulation and functional enrichment for MM Myeloma Zhan cluster number 51. Information about myeloma can be found on Wikipedia, and further information about the "MM Myeloma Zhan" dataset can be found in Zhan et al., 2002.

Weeder-miRvestigator	PITA	TargetScan
zzz999	zzz999	zzz999

GO ID	GO Term	Annotated Genes in Cluster
GO:0000003	reproduction	180
GO:0000075	cell cycle checkpoint	39
GO:0000082	G1/S transition of mitotic cell cycle	40
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	8
GO:0000084	S phase of mitotic cell cycle	28
GO:0000087	M phase of mitotic cell cycle	44
GO:0000216	M/G1 transition of mitotic cell cycle	15
GO:0000278	mitotic cell cycle	97
GO:0000279	M phase	59
GO:0000722	telomere maintenance via recombination	7
GO:0001503	ossification	34
GO:0001525	angiogenesis	21
GO:0001568	blood vessel development	51
GO:0001649	osteoblast differentiation	21
GO:0001701	in utero embryonic development	33
GO:0001708	cell fate specification	10
GO:0001775	cell activation	88
GO:0001777	T cell homeostatic proliferation	2
GO:0001932	regulation of protein phosphorylation	73
GO:0001933	negative regulation of protein phosphorylation	12
GO:0001944	vasculature development	51
GO:0001975	response to amphetamine	8
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	2
GO:0002252	immune effector process	41
GO:0002376	immune system process	165
GO:0002443	leukocyte mediated immunity	23
GO:0002526	acute inflammatory response	19
GO:0002682	regulation of immune system process	88
GO:0002684	positive regulation of immune system process	57
GO:0002697	regulation of immune effector process	25
GO:0003002	regionalization	33
GO:0003006	developmental process involved in reproduction	42
GO:0003008	system process	172
GO:0003013	circulatory system process	56
GO:0003015	heart process	19
GO:0003018	vascular process in circulatory system	23
GO:0003073	regulation of systemic arterial blood pressure	11
GO:0006066	alcohol metabolic process	65
GO:0006091	generation of precursor metabolites and energy	54
GO:0006094	gluconeogenesis	13
GO:0006112	energy reserve metabolic process	25
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	437
GO:0006140	regulation of nucleotide metabolic process	38
GO:0006171	cAMP biosynthetic process	24
GO:0006259	DNA metabolic process	85
GO:0006260	DNA replication	45
GO:0006261	DNA-dependent DNA replication	22
GO:0006270	DNA-dependent DNA replication initiation	11
GO:0006271	DNA strand elongation involved in DNA replication	13
GO:0006302	double-strand break repair	16
GO:0006310	DNA recombination	29
GO:0006312	mitotic recombination	9
GO:0006350	transcription, DNA-dependent	297
GO:0006357	regulation of transcription from RNA polymerase II promoter	107
GO:0006364	rRNA processing	16
GO:0006366	transcription from RNA polymerase II promoter	121
GO:0006412	translation	89
GO:0006414	translational elongation	68
GO:0006415	translational termination	64
GO:0006468	protein phosphorylation	126
GO:0006568	tryptophan metabolic process	5
GO:0006576	cellular biogenic amine metabolic process	21
GO:0006586	indolalkylamine metabolic process	9
GO:0006606	protein import into nucleus	25
GO:0006694	steroid biosynthetic process	25
GO:0006725	cellular aromatic compound metabolic process	34
GO:0006738	nicotinamide riboside catabolic process	2
GO:0006753	nucleoside phosphate metabolic process	71
GO:0006793	phosphorus metabolic process	154
GO:0006796	phosphate metabolic process	154
GO:0006807	nitrogen compound metabolic process	489
GO:0006873	cellular ion homeostasis	58
GO:0006874	cellular calcium ion homeostasis	37
GO:0006875	cellular metal ion homeostasis	42
GO:0006915	apoptosis	154
GO:0006917	induction of apoptosis	55
GO:0006939	smooth muscle contraction	18
GO:0006950	response to stress	305
GO:0006952	defense response	109
GO:0006953	acute-phase response	12
GO:0006954	inflammatory response	52
GO:0007049	cell cycle	157
GO:0007154	cell communication	202
GO:0007165	signal transduction	364
GO:0007166	cell surface receptor linked signaling pathway	224
GO:0007167	enzyme linked receptor protein signaling pathway	103
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	76
GO:0007186	G-protein coupled receptor protein signaling pathway	67
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	25
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	22
GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	11
GO:0007190	activation of adenylate cyclase activity	15
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling pathway	10
GO:0007194	negative regulation of adenylate cyclase activity	12
GO:0007267	cell-cell signaling	126
GO:0007268	synaptic transmission	68
GO:0007275	multicellular organismal development	429
GO:0007320	insemination	5
GO:0007346	regulation of mitotic cell cycle	42
GO:0007399	nervous system development	161
GO:0007417	central nervous system development	60
GO:0007507	heart development	45
GO:0007565	female pregnancy	22
GO:0007568	aging	28
GO:0007588	excretion	14
GO:0007596	blood coagulation	78
GO:0007599	hemostasis	80
GO:0007610	behavior	53
GO:0007625	grooming behavior	4
GO:0007631	feeding behavior	17
GO:0008015	blood circulation	56
GO:0008016	regulation of heart contraction	18
GO:0008152	metabolic process	799
GO:0008202	steroid metabolic process	39
GO:0008217	regulation of blood pressure	26
GO:0008283	cell proliferation	179
GO:0008284	positive regulation of cell proliferation	71
GO:0008285	negative regulation of cell proliferation	59
GO:0008406	gonad development	25
GO:0008584	male gonad development	18
GO:0009056	catabolic process	141
GO:0009058	biosynthetic process	481
GO:0009059	macromolecule biosynthetic process	372
GO:0009063	cellular amino acid catabolic process	17
GO:0009072	aromatic amino acid family metabolic process	10
GO:0009074	aromatic amino acid family catabolic process	8
GO:0009117	nucleotide metabolic process	71
GO:0009165	nucleotide biosynthetic process	48
GO:0009187	cyclic nucleotide metabolic process	32
GO:0009190	cyclic nucleotide biosynthetic process	26
GO:0009310	amine catabolic process	18
GO:0009314	response to radiation	38
GO:0009605	response to external stimulus	134
GO:0009611	response to wounding	143
GO:0009628	response to abiotic stimulus	67
GO:0009653	anatomical structure morphogenesis	183
GO:0009719	response to endogenous stimulus	108
GO:0009725	response to hormone stimulus	94
GO:0009790	embryo development	80
GO:0009792	embryo development ending in birth or egg hatching	52
GO:0009887	organ morphogenesis	76
GO:0009888	tissue development	111
GO:0009891	positive regulation of biosynthetic process	96
GO:0009892	negative regulation of metabolic process	117
GO:0009893	positive regulation of metabolic process	139
GO:0009914	hormone transport	33
GO:0009987	cellular process	1054
GO:0009991	response to extracellular stimulus	45
GO:0010033	response to organic substance	171
GO:0010035	response to inorganic substance	49
GO:0010038	response to metal ion	40
GO:0010043	response to zinc ion	8
GO:0010243	response to organic nitrogen	21
GO:0010467	gene expression	361
GO:0010520	regulation of reciprocal meiotic recombination	2
GO:0010563	negative regulation of phosphorus metabolic process	17
GO:0010564	regulation of cell cycle process	64
GO:0010578	regulation of adenylate cyclase activity involved in G-protein signaling pathway	11
GO:0010579	positive regulation of adenylate cyclase activity by G-protein signaling pathway	11
GO:0010604	positive regulation of macromolecule metabolic process	124
GO:0010605	negative regulation of macromolecule metabolic process	107
GO:0010700	negative regulation of norepinephrine secretion	3
GO:0010701	positive regulation of norepinephrine secretion	3
GO:0010817	regulation of hormone levels	51
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	6
GO:0012501	programmed cell death	154
GO:0012502	induction of programmed cell death	55
GO:0014061	regulation of norepinephrine secretion	6
GO:0014075	response to amine stimulus	16
GO:0015874	norepinephrine transport	6
GO:0016032	viral reproduction	102
GO:0016043	cellular component organization	375
GO:0016072	rRNA metabolic process	16
GO:0016310	phosphorylation	137
GO:0017038	protein import	30
GO:0017085	response to insecticide	4
GO:0019058	viral infectious cycle	78
GO:0019080	viral genome expression	67
GO:0019083	viral transcription	67
GO:0019220	regulation of phosphate metabolic process	83
GO:0019222	regulation of metabolic process	399
GO:0019226	transmission of nerve impulse	75
GO:0019229	regulation of vasoconstriction	9
GO:0019319	hexose biosynthetic process	13
GO:0019363	pyridine nucleotide biosynthetic process	5
GO:0019439	aromatic compound catabolic process	9
GO:0019538	protein metabolic process	336
GO:0019805	quinolinate biosynthetic process	3
GO:0019932	second-messenger-mediated signaling	52
GO:0019933	cAMP-mediated signaling	26
GO:0019935	cyclic-nucleotide-mediated signaling	29
GO:0022402	cell cycle process	128
GO:0022403	cell cycle phase	108
GO:0022411	cellular component disassembly	83
GO:0022414	reproductive process	179
GO:0022415	viral reproductive process	79
GO:0022616	DNA strand elongation	13
GO:0030003	cellular cation homeostasis	45
GO:0030154	cell differentiation	227
GO:0030238	male sex determination	5
GO:0030278	regulation of ossification	18
GO:0030799	regulation of cyclic nucleotide metabolic process	26
GO:0030802	regulation of cyclic nucleotide biosynthetic process	25
GO:0030808	regulation of nucleotide biosynthetic process	25
GO:0030814	regulation of cAMP metabolic process	25
GO:0030817	regulation of cAMP biosynthetic process	24
GO:0031016	pancreas development	72
GO:0031018	endocrine pancreas development	69
GO:0031099	regeneration	17
GO:0031214	biomineral tissue development	15
GO:0031279	regulation of cyclase activity	24
GO:0031280	negative regulation of cyclase activity	12
GO:0031281	positive regulation of cyclase activity	15
GO:0031294	lymphocyte costimulation	13
GO:0031295	T cell costimulation	13
GO:0031324	negative regulation of cellular metabolic process	105
GO:0031325	positive regulation of cellular metabolic process	128
GO:0031328	positive regulation of cellular biosynthetic process	95
GO:0031644	regulation of neurological system process	27
GO:0031645	negative regulation of neurological system process	9
GO:0031667	response to nutrient levels	38
GO:0031960	response to corticosteroid stimulus	18
GO:0032101	regulation of response to external stimulus	32
GO:0032201	telomere maintenance via semi-conservative replication	8
GO:0032268	regulation of cellular protein metabolic process	104
GO:0032276	regulation of gonadotropin secretion	3
GO:0032277	negative regulation of gonadotropin secretion	3
GO:0032355	response to estradiol stimulus	18
GO:0032501	multicellular organismal process	599
GO:0032502	developmental process	459
GO:0032504	multicellular organism reproduction	68
GO:0032570	response to progesterone stimulus	7
GO:0032583	regulation of transcription, DNA-dependent	57
GO:0032879	regulation of localization	114
GO:0032911	negative regulation of transforming growth factor beta1 production	2
GO:0032943	mononuclear cell proliferation	22
GO:0032984	macromolecular complex disassembly	72
GO:0033127	regulation of histone phosphorylation	2
GO:0033627	cell adhesion mediated by integrin	7
GO:0034621	cellular macromolecular complex subunit organization	111
GO:0034623	cellular macromolecular complex disassembly	72
GO:0034641	cellular nitrogen compound metabolic process	483
GO:0034645	cellular macromolecule biosynthetic process	365
GO:0035150	regulation of tube size	22
GO:0035270	endocrine system development	78
GO:0042053	regulation of dopamine metabolic process	4
GO:0042060	wound healing	95
GO:0042110	T cell activation	38
GO:0042127	regulation of cell proliferation	130
GO:0042221	response to chemical stimulus	278
GO:0042254	ribosome biogenesis	20
GO:0042273	ribosomal large subunit biogenesis	5
GO:0042274	ribosomal small subunit biogenesis	9
GO:0042310	vasoconstriction	11
GO:0042311	vasodilation	10
GO:0042312	regulation of vasodilation	7
GO:0042325	regulation of phosphorylation	79
GO:0042326	negative regulation of phosphorylation	16
GO:0042428	serotonin metabolic process	4
GO:0042430	indole-containing compound metabolic process	9
GO:0042493	response to drug	48
GO:0042592	homeostatic process	122
GO:0042594	response to starvation	15
GO:0042713	sperm ejaculation	3
GO:0042755	eating behavior	8
GO:0042981	regulation of apoptosis	132
GO:0043009	chordate embryonic development	51
GO:0043065	positive regulation of apoptosis	75
GO:0043067	regulation of programmed cell death	132
GO:0043068	positive regulation of programmed cell death	75
GO:0043085	positive regulation of catalytic activity	83
GO:0043170	macromolecule metabolic process	597
GO:0043241	protein complex disassembly	72
GO:0043434	response to peptide hormone stimulus	53
GO:0043624	cellular protein complex disassembly	72
GO:0043627	response to estrogen stimulus	27
GO:0043933	macromolecular complex subunit organization	150
GO:0043949	regulation of cAMP-mediated signaling	4
GO:0043950	positive regulation of cAMP-mediated signaling	2
GO:0044057	regulation of system process	59
GO:0044237	cellular metabolic process	735
GO:0044238	primary metabolic process	740
GO:0044249	cellular biosynthetic process	470
GO:0044260	cellular macromolecule metabolic process	552
GO:0044267	cellular protein metabolic process	301
GO:0045103	intermediate filament-based process	6
GO:0045137	development of primary sexual characteristics	26
GO:0045165	cell fate commitment	28
GO:0045321	leukocyte activation	57
GO:0045471	response to ethanol	18
GO:0045667	regulation of osteoblast differentiation	15
GO:0045669	positive regulation of osteoblast differentiation	14
GO:0045730	respiratory burst	8
GO:0045761	regulation of adenylate cyclase activity	24
GO:0045762	positive regulation of adenylate cyclase activity	15
GO:0045776	negative regulation of blood pressure	8
GO:0045777	positive regulation of blood pressure	10
GO:0045778	positive regulation of ossification	8
GO:0045787	positive regulation of cell cycle	22
GO:0045822	negative regulation of heart contraction	5
GO:0045840	positive regulation of mitosis	8
GO:0045931	positive regulation of mitotic cell cycle	10
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	90
GO:0045936	negative regulation of phosphate metabolic process	17
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	58
GO:0046013	regulation of T cell homeostatic proliferation	2
GO:0046058	cAMP metabolic process	28
GO:0046483	heterocycle metabolic process	89
GO:0046495	nicotinamide riboside metabolic process	2
GO:0046546	development of primary male sexual characteristics	19
GO:0046649	lymphocyte activation	51
GO:0046651	lymphocyte proliferation	22
GO:0046661	male sex differentiation	21
GO:0046686	response to cadmium ion	8
GO:0046717	acid secretion	7
GO:0046879	hormone secretion	31
GO:0046880	regulation of follicle-stimulating hormone secretion	3
GO:0046882	negative regulation of follicle-stimulating hormone secretion	3
GO:0046883	regulation of hormone secretion	26
GO:0046903	secretion	95
GO:0046958	nonassociative learning	2
GO:0046960	sensitization	2
GO:0048243	norepinephrine secretion	6
GO:0048468	cell development	124
GO:0048513	organ development	282
GO:0048514	blood vessel morphogenesis	43
GO:0048518	positive regulation of biological process	312
GO:0048519	negative regulation of biological process	272
GO:0048522	positive regulation of cellular process	275
GO:0048523	negative regulation of cellular process	250
GO:0048545	response to steroid hormone stimulus	49
GO:0048608	reproductive structure development	31
GO:0048609	multicellular organismal reproductive process	68
GO:0048646	anatomical structure formation involved in morphogenesis	75
GO:0048731	system development	389
GO:0048856	anatomical structure development	417
GO:0048869	cellular developmental process	228
GO:0048878	chemical homeostasis	83
GO:0050789	regulation of biological process	685
GO:0050790	regulation of catalytic activity	123
GO:0050793	regulation of developmental process	105
GO:0050794	regulation of cellular process	656
GO:0050801	ion homeostasis	63
GO:0050804	regulation of synaptic transmission	24
GO:0050805	negative regulation of synaptic transmission	7
GO:0050817	coagulation	78
GO:0050878	regulation of body fluid levels	94
GO:0050880	regulation of blood vessel size	22
GO:0050896	response to stimulus	600
GO:0051023	regulation of immunoglobulin secretion	4
GO:0051046	regulation of secretion	47
GO:0051048	negative regulation of secretion	18
GO:0051049	regulation of transport	91
GO:0051050	positive regulation of transport	49
GO:0051051	negative regulation of transport	27
GO:0051052	regulation of DNA metabolic process	28
GO:0051054	positive regulation of DNA metabolic process	15
GO:0051094	positive regulation of developmental process	59
GO:0051170	nuclear import	25
GO:0051174	regulation of phosphorus metabolic process	83
GO:0051239	regulation of multicellular organismal process	155
GO:0051240	positive regulation of multicellular organismal process	48
GO:0051241	negative regulation of multicellular organismal process	35
GO:0051246	regulation of protein metabolic process	111
GO:0051262	protein tetramerization	11
GO:0051291	protein heterooligomerization	13
GO:0051320	S phase	30
GO:0051325	interphase	65
GO:0051329	interphase of mitotic cell cycle	62
GO:0051339	regulation of lyase activity	24
GO:0051349	positive regulation of lyase activity	15
GO:0051350	negative regulation of lyase activity	12
GO:0051480	cytosolic calcium ion homeostasis	26
GO:0051592	response to calcium ion	15
GO:0051641	cellular localization	162
GO:0051649	establishment of localization in cell	147
GO:0051704	multi-organism process	123
GO:0051716	cellular response to stimulus	442
GO:0051726	regulation of cell cycle	95
GO:0051969	regulation of transmission of nerve impulse	26
GO:0051970	negative regulation of transmission of nerve impulse	9
GO:0055065	metal ion homeostasis	44
GO:0055074	calcium ion homeostasis	38
GO:0055080	cation homeostasis	49
GO:0055082	cellular chemical homeostasis	59
GO:0055086	nucleobase, nucleoside and nucleotide metabolic process	76
GO:0060047	heart contraction	19
GO:0060263	regulation of respiratory burst	4
GO:0060341	regulation of cellular localization	59
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	7
GO:0065007	biological regulation	744
GO:0065008	regulation of biological quality	289
GO:0065009	regulation of molecular function	149

miRNA	Method	GO ID	GO Term	Overlap	GO Annotated Genes	Cluster Size	miRNA Targets Genes	P-Value

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